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Effect of the test compounds on ergosterol biosynthesis in different <t> fluconazole-sensitive </t> and fluconazole-resistant Candida isolates.
Fluconazole (Flc), supplied by HiMedia Laboratories, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Effect of the test compounds on ergosterol biosynthesis in different <t> fluconazole-sensitive </t> and fluconazole-resistant Candida isolates.
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Effect of the test compounds on ergosterol biosynthesis in different <t> fluconazole-sensitive </t> and fluconazole-resistant Candida isolates.
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Effect of the test compounds on ergosterol biosynthesis in different <t> fluconazole-sensitive </t> and fluconazole-resistant Candida isolates.
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Image Search Results


Effect of the test compounds on ergosterol biosynthesis in different fluconazole-sensitive and fluconazole-resistant Candida isolates.

Journal: International Journal of Molecular Sciences

Article Title: Synthesis, Structure Optimization and Antifungal Screening of Novel Tetrazole Ring Bearing Acyl-Hydrazones

doi: 10.3390/ijms130910880

Figure Lengend Snippet: Effect of the test compounds on ergosterol biosynthesis in different fluconazole-sensitive and fluconazole-resistant Candida isolates.

Article Snippet: Fluconazole (FLC) and Amphotericin B (AmB) were procured from HiMedia.

Techniques: Control

UV spectrophotometric sterol profiles of representative susceptible Candida isolates. Isolates were grown for 16 h in sabouraud dextrose broth containing 0 (curve a), ½ MIC’s of compounds— TH1 (curve b), TH2 (curve c), TH3 (curve d), TH4 (curve e), TH5 (curve f), TH6 (curve l), TH7 (curve m), TH8 (curve n), TH9 (curve o), TH10 (curve p) or MIC’s of compounds TH1 (curve g), TH2 (curve h), TH3 (curve i), TH4 (curve j), TH5 (curve k), TH6 (curve q), TH7 (curve r), TH8 (curve s), TH9 (curve t), TH10 (curve u) or 64 mg of fluconazole per L (curve v). Curves A1 , A2 , A3 , A4 and A5 represent cells treated with 125 mg L −1 of their respective intermediates. Sterols were extracted from cells, and spectral profiles between 240 and 300 nm were determined. X -axis represents the wavelength between 240 nm and 300 nm.

Journal: International Journal of Molecular Sciences

Article Title: Synthesis, Structure Optimization and Antifungal Screening of Novel Tetrazole Ring Bearing Acyl-Hydrazones

doi: 10.3390/ijms130910880

Figure Lengend Snippet: UV spectrophotometric sterol profiles of representative susceptible Candida isolates. Isolates were grown for 16 h in sabouraud dextrose broth containing 0 (curve a), ½ MIC’s of compounds— TH1 (curve b), TH2 (curve c), TH3 (curve d), TH4 (curve e), TH5 (curve f), TH6 (curve l), TH7 (curve m), TH8 (curve n), TH9 (curve o), TH10 (curve p) or MIC’s of compounds TH1 (curve g), TH2 (curve h), TH3 (curve i), TH4 (curve j), TH5 (curve k), TH6 (curve q), TH7 (curve r), TH8 (curve s), TH9 (curve t), TH10 (curve u) or 64 mg of fluconazole per L (curve v). Curves A1 , A2 , A3 , A4 and A5 represent cells treated with 125 mg L −1 of their respective intermediates. Sterols were extracted from cells, and spectral profiles between 240 and 300 nm were determined. X -axis represents the wavelength between 240 nm and 300 nm.

Article Snippet: Fluconazole (FLC) and Amphotericin B (AmB) were procured from HiMedia.

Techniques:

UV spectrophotometric sterol profiles of representative resistant Candida isolates. Isolates were grown for 16 h in sabouraud dextrose broth containing 0 (curve a), ½ MIC’s of compounds— TH1 (curve b), TH2 (curve c), TH3 (curve d), TH4 (curve e), TH5 (curve f), TH6 (curve l), TH7 (curve m), TH8 (curve n), TH9 (curve o), TH10 (curve p) or MIC’s of compounds— TH1 (curve g), TH2 (curve h), TH3 (curve i), TH4 (curve j), TH5 (curve k), TH6 (curve q), TH7 (curve r), TH8 (curve s), TH9 (curve t), TH10 (curve u) or 64 mg of fluconazole per liter (curve v). Sterols were extracted from cells, and spectral profiles between 240 and 300 nm were determined. X -axis represents the wavelength between 240 nm and 300 nm.

Journal: International Journal of Molecular Sciences

Article Title: Synthesis, Structure Optimization and Antifungal Screening of Novel Tetrazole Ring Bearing Acyl-Hydrazones

doi: 10.3390/ijms130910880

Figure Lengend Snippet: UV spectrophotometric sterol profiles of representative resistant Candida isolates. Isolates were grown for 16 h in sabouraud dextrose broth containing 0 (curve a), ½ MIC’s of compounds— TH1 (curve b), TH2 (curve c), TH3 (curve d), TH4 (curve e), TH5 (curve f), TH6 (curve l), TH7 (curve m), TH8 (curve n), TH9 (curve o), TH10 (curve p) or MIC’s of compounds— TH1 (curve g), TH2 (curve h), TH3 (curve i), TH4 (curve j), TH5 (curve k), TH6 (curve q), TH7 (curve r), TH8 (curve s), TH9 (curve t), TH10 (curve u) or 64 mg of fluconazole per liter (curve v). Sterols were extracted from cells, and spectral profiles between 240 and 300 nm were determined. X -axis represents the wavelength between 240 nm and 300 nm.

Article Snippet: Fluconazole (FLC) and Amphotericin B (AmB) were procured from HiMedia.

Techniques: